Microsatellite instability in nonendometrioid ovarian epithelial tumors: a study of 400 cases comparing immunohistochemistry, PCR, and NGS based testing with mutation status of MMR genes

Testing of microsatellite instability is not only used as a triage for possible Lynch syndrome, but also to predict immunotherapy treatment response. The aim of this study was to assess the frequency of mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) in 400 cases of nonendometrioid ovarian tumors (high-grade serous, low-grade serous, mucinous and clear cell), to compare different methodological approaches of testing, and to assess the optimal approach for next generation sequencing (NGS) MSI testing.

Source: Translational Research - May 24, 2023 Category: Research Authors: Nikola H ájková, Michaela Kendall Bártů, David Cibula, Jana Drozenová, Pavel Fabian, Oluwole Fadare, Filip Frühauf, Jitka Hausnerová, Jan hojný, Eva Krkavcová, Jan Laco, Sigurd F. Lax, Radoslav Matěj, Gábor Méhes, Romana Michálková, Kristýn Source Type: research