Hepatic insulin receptor: new views on the mechanisms of liver disease

Over 65  % of people with obesity display the metabolic-associated fatty liver disease (MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The development and progression of MAFLD involve hepatic insulin resistance and reduced insulin clearance. This review discusses the relationships between altered insulin signaling, hepatic insulin resistance, and reduced insulin clearance in the development of MAFLD and how this provides the impetus for exploring the use of insulin sensitizers to curb this disease.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Tags: Review Source Type: research