Polymerized human hemoglobin with low and high oxygen affinity in trauma models

The present study aimed to compare the ability of tense (T) and relax R-state polymerized human Hemoglobin (PolyhHbs) to restore hemodynamics after severe trauma in a rat model, and to assess their relative toxicity in a guinea pigs (GPs). To assess the efficacy of these PolyhHbs in restoring hemodynamics, Wistar rats were subjected to traumatic brain injury (TBI) followed by hemorrhagic shock (HS). Animals were separated into 3 groups based on the resuscitation solution: Whole Blood, T-state or R-state PolyhHb, and followed for 2 hours after resuscitation.

Source: Translational Research - May 31, 2023 Category: Research Authors: Cynthia R. Muller, Vasiliki Courelli, Cynthia Walser, Clayton T. Cuddington, Savannah R. Wolfe, Andre F. Palmer, Pedro Cabrales Source Type: research