Hemiplegic Migraine

AbstractPurpose of ReviewIn this article, we review recent updates to the epidemiology, diagnostic testing, genetics, pathophysiology, and management of hemiplegic migraine.Recent FindingsWhile three genes have been historically associated with hemiplegic migraine, recent studies suggest two additional genes may also be implicated includingPPRT2 andSLC1A3.SummaryHemiplegic migraine is a severe subset of migraine with aura with symptoms including reversible hemiparesis in addition to other aura symptoms such as visual, sensory, or speech. The exact pathophysiology of hemiplegic migraine is not clear, but it is thought that this phenomenon is due to neuronal and glial depolarization causing cortical spreading depression. Due to the severity of presentation as well as the numerous mimickers, it is important to know a comprehensive differential and work-up. Given the low prevalence of the disease, most studies regarding treatment are limited to case studies. There is still an important need for further and larger studies regarding management of these cases.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research