Associated genetic variants and potential pathogenic mechanisms of brain arteriovenous malformation

Conclusions
According to our meta-analysis, ACVRL1 rs2071219 and CDKN2B-AS1 rs1333040 were potentially associated with bAVM. Multiple pathological signaling pathways could affect disease development. Future studies should aim to determine the interaction of candidate genes with environmental risk factors and to elucidate detailed mechanisms of action of variants and genes.
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Source: Journal of NeuroInterventional Surgery - May 16, 2023 Category: Neurosurgery Authors: Liu, J., Li, Y., Zhang, H., Luo, C., Yuan, D., Jiang, W., Yan, J. Tags: Hemorrhagic stroke Source Type: research