BPTF in bone marrow provides a potential progression biomarker regulated by TFAP4 through the PI3K/AKT pathway in neuroblastoma

CONCLUSIONS: A novel and convenient BPTF-targeted humoral detection that can prompt minimal residual and predict NB progression in the early stages of the disease were identified. BPTF inhibitor AU1 is expected to become a new targeted drug for NB therapy. It's also reveal previously unknown mechanisms of BPTF in NB cell proliferation and metastasis through TFAP4 and PI3K/AKT pathways.PMID:37170211 | PMC:PMC10176855 | DOI:10.1186/s12575-023-00200-7

Source: Biological Procedures Online - May 11, 2023 Category: Molecular Biology Authors: Chiyi Jiang Yeran Yang Sidou He Zhixia Yue Tianyu Xing Ping Chu Wenfa Yang Hui Chen Xiaoxi Zhao Yongbo Yu Xuan Zhang Yan Su Yongli Guo Xiaoli Ma Source Type: research