Reactive oxygen species produced by myeloid cells in psoriasis as a potential biofactor contributing to the development of vascular inflammation
In the autoimmune skin disease psoriasis, an overproduction of interleukin-17A and interleukin-23 leads to an aberrant activation of keratinocytes, influx of myeloid cells and skin inflammation. These inflammatory conditions led to a higher activation of neutrophil granulocytes in a mouse model of chronic severe psoriasis based on IL-17A overexpression in the skin (K14-IL-17Aind/+ mice versus IL-17Aind/+ controls) seen by upregulated production of reactive oxygen species (ROS) and significant increase of mRNA expression ofmyeloperoxidase (Mpo),proteinase 3 (Prt3), andneutrophil elastase (Elane). In skin of psoriatic mice, increased ROS-levels were detected and we had previously also found increased ROS levels in the aortic vessel wall. In both skin and aorta, significantly increased mRNA-expression levels ofChemokine (C-X-C motif)ligand 2 (Cxcl2) andS100 calcium-binding protein A9 (S100a9) were detected. No direct migration of myeloid cells from the inflamed skin into the vasculature was found in K14-IL-17Aind/+ psoriatic mice, so ROS producing myeloid cells were most likely bone marrow derived underlining the systemic effects of the disease. AbstractPsoriasis is an immune-mediated inflammatory skin disease driven by interleukin-17A (IL-17A) and associated with cardiovascular dysfunction. We used a severe psoriasis mouse model of keratinocyte IL-17A overexpression (K14-IL-17Aind/+, IL-17Aind/+ control mice) to investigate the activity of neutrophils and a potential cellular i...
Source: BioFactors - Category: Biochemistry Authors: Theresa Schaller,
Julia Ringen,
Berenice Fischer,
Tabea Bieler,
Katharina Perius,
Tanja Knopp,
Katharina S. Kommoss,
Thomas Korn,
Mathias Heikenw älder,
Matthias Oelze,
Andreas Daiber,
Thomas Münzel,
Daniela Kramer,
Philip Wenzel,
Johannes Tags: RESEARCH ARTICLE Source Type: research
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