Adherence to a  healthy lifestyle and brain structural imaging markers

We examined the association of adherence to a healthy lifestyle with a panel of brain structural markers among 2,413 participants in PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study in China and 19,822 participants in UK Biobank (UKB). A healthy lifestyle score (0 –5) was constructed based on five modifiable lifestyle factors: diet, physical activity, smoking, alcohol consumption, and body mass index. Validated multimodal neuroimaging markers were derived from brain magnetic resonance imaging. In the cross-sectional analysis of PRECISE, participants who ado pted four or five low-risk lifestyle factors had larger total brain volume (TBV; β = 0.12, 95% CI: − 0.02, 0.26;p-trend = 0.05) and gray matter volume (GMV; β = 0.16, 95% CI: 0.01, 0.30;p-trend = 0.05), smaller white matter hyperintensity volume (WMHV; β = − 0.35, 95% CI: − 0.50, − 0.20;p-trend <  0.001) and lower odds of lacune (Odds Ratio [OR] = 0.48, 95% CI: 0.22, 1.08;p-trend = 0.03), compared to those with zero or one low-risk factors. Meanwhile, in the prospective analysis in UKB (with a median of 7.7 years’ follow-up), similar associations were observed between the number of low-risk lifestyle factors (4–5 vs. 0–1) and TBV (β = 0.22, 95% CI: 0.16, 0.2 8;p-trend <  0.001), GMV (β = 0.26, 95% CI: 0.21, 0.32;p-trend <  0.001), white matter volume (WMV; β = 0.08, 95% CI: 0.01, 0.15;p-trend =â...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research