Apolipoprotein E (ApoE) genes: rs429358 and rs7412

The apolipoprotein E (ApoE) gene makes a protein which, when combined with fat, becomes a lipoprotein.The lipoprotein ApoE is a very low-density lipoprotein, responsible in part for removing cholesterol from the bloodstream. Variations in ApoE affect cholesterol metabolism, which in turn alter your chances of having heart disease and in particular a heart attack or a stroke. Variations in ApoE are also associated with altered odds of having Alzheimer's disease and other diseases.There are3 allelic variants of ApoE, as defined by two SNPs,rs429358 and rs7412 known as:- ApoE- ε2- ApoE- ε3- ApoE- ε4The proteins produced by these genes are called ApoE2, ApoE3, and ApoE4.The most common variant overall is the "standard" ApoE- ε3, and therefore more people inherited one ApoE-ε3 from each parent than any other of the possible pairs of variants. Apo- ε2/ε2- rs429358 and rs7412 (T;T) (T;T) -has the lowest risk. Apo- ε3/ε3 - rs429358 and rs7412 (T;T) (C;C) - is the the most common.Apo- ε4/ε4  - rs429358 and rs7412(C;C) (C;C) - has 11 times higher increased Alzheimer's risk. References:https://www.snpedia.com/index.php/APOE Posted atClinical Cases and Images. Stay updated andsubscribe, follow us onTwitter and connect onFacebook.
Source: Clinical Cases and Images - Blog - Category: Universities & Medical Training Tags: Genetics Source Type: blogs