Risk-prediction models for intravenous immunoglobulin resistance in Kawasaki disease: Risk-of-Bias Assessment using PROBAST

CONCLUSION: IVIG resistance models for Kawasaki disease showed high ROB. An emphasis on improving their quality can provide high-quality evidence for clinical practice.IMPACT STATEMENT: This study systematically evaluated the risk of bias (ROB) of existing prediction models for intravenous immunoglobulin (IVIG) resistance in Kawasaki disease to provide guidance for future model development meeting clinical expectations. This is the first study to systematically evaluate the ROB of IVIG resistance in Kawasaki disease by using PROBAST. ROB may reduce model performance in different populations. Future prediction models should account for this problem, and PROBAST can help improve the methodological quality and applicability of prediction model development.PMID:36964445 | DOI:10.1038/s41390-023-02558-6

Source: Pediatric Research - March 25, 2023 Category: Pediatrics Authors: Shuhui Wang Hongbiao Huang Miao Hou Qiuqin Xu Weiguo Qian Yunjia Tang Xuan Li Guanghui Qian Jin Ma Yiming Zheng Yueping Shen Haitao Lv Source Type: research