Silicon nanowire array overcomes chemotherapeutic resistance by inducing the differentiation of breast cancer stem cells

In this study, we report the SiNWA differentiates MCF-7-derived breast CSCs (BCSCs) into non-CSCs by modulating the morphology of cells. In vitro, the differentiated BCSCs lose the stemness properties and thus become sensitive to chemotherapeutic drugs, eventually leading to the death of BCSCs. Therefore, this work suggests a potential approach for overcoming chemotherapeutic resistance.

Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 17, 2023 Category: Materials Science Authors: Xiaotong Wang, Sisi Liu, Wei Zhang, Haotong Peng, Miao Zhang, Yaping Li, Qi Guo, Wenjing Wang, Na Huang, LiYan Liu, Dandan Liu Tags: RESEARCH ARTICLE Source Type: research