Development of direct cardiac reprogramming for clinical applications
The incidence of cardiovascular diseases is increasing worldwide, and cardiac regenerative therapy has great potential as a new treatment strategy, especially for ischemic heart disease. Direct cardiac reprogramming is a promising new cardiac regenerative therapy that uses defined factors to induce transdifferentiation of endogenous cardiac fibroblasts (CFs) into induced cardiomyocyte-like cells (iCMs). In vivo reprogramming is expected to restore lost cardiac function without necessitating cardiac transplantation by converting endogenous CFs that exist abundantly in cardiac tissues directly into iCMs.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Yu Yamada, Taketaro Sadahiro, Masaki Ieda Tags: Review article Source Type: research
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