Effectiveness of therapeutic plasma exchange in case of rare neurological disorder Isaacs syndrome

Parmatma Prasad Tripathi, Sangeeta Kumari, Nandita Prabhat, Divjot Singh Lamba, Rekha Hans, Manoj Kumar Goyal, Vivek Lal, Ratti Ram SharmaAsian Journal of Transfusion Science 2023 17(1):117-120 Isaacs syndrome is a disease characterized by nerve hyperexcitability and pseudomyotonia and treated with immunomodulatory and symptomatic therapy approaches. Here, we report a case of anti-(leucine-rich glioma-inactivated 1) antibody-positive patient diagnosed as Isaacs syndrome and accomplished a nearly complete response to only four sessions of therapeutic plasma exchange (TPE). Our experience suggests that TPE along with other immunomodulatory agents may be beneficial and well-tolerated approach in patient with Isaacs syndrome.
Source: Asian Journal of Transfusion Science - Category: Hematology Authors: Source Type: research