Multi T1-weighted contrast imaging and T1 mapping with compressed sensing FLAWS at 3  T

This study aims at reducing the FLAWS acquisition time by providing a new sequence optimization based on a Cartesian phyllotaxis k-space undersampling and a compressed sensing (CS) reconstruction. This study also aims at showing that T1 map ping can be performed with FLAWS at 3 T.Materials and methodsThe CS FLAWS parameters were determined using a method based on a profit function maximization under constraints. The FLAWS optimization and T1 mapping were assessed with in-silico, in-vitro and in-vivo (10 healthy volunteers) experiments conducted at 3  T.ResultsIn-silico, in-vitro and in-vivo experiments showed that the proposed CS FLAWS optimization allows the acquisition time of a 1  mm-isotropic full-brain scan to be reduced from\(8 \mathrm{mins}\) to\(6 \mathrm{mins}\) without decreasing image quality. In addition, these experiments demonstrate that T1 mapping can be performed with FLAWS at 3  T.DiscussionThe results obtained in this study suggest that the recent advances in FLAWS imaging allow to perform multiple T1-weighted contrast imaging and T1 mapping in a single\(6 \mathrm{mins}\) sequence acquisition.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - Category: Materials Science Source Type: research