The Aryl Hydrocarbon Receptor Ligand 6-Formylindolo(3,2-b)carbazole Promotes Estrogen Receptor Alpha and c-Fos Protein Degradation and Inhibits MCF-7 Cell Proliferation and Migration

Conclusions: Activation of AHR results in a decreased MCF-7 cell proliferation and migration by ER α and c-Fos down regulation. Targeting AHR might be a promising therapy for breast cancer treatment, particularly when estrogen-independent ERα reactivation presents.Pharmacology
Source: Pharmacology - Category: Drugs & Pharmacology Source Type: research