Perioperative Nutritional Status and Organ Dysfunction Following Surgery for Congenital Heart Disease

AbstractChildren with congenital heart disease (CHD) are at risk of malnutrition; however, there is limited information regarding the impact of nutritional status on organ dysfunction and outcomes after surgery for CHD. The study aim was to assess the association between malnutrition, organ dysfunction, and outcomes after surgery for CHD. Retrospective cohort study of patients aged 30  days to 18 years admitted to the cardiac intensive care unit (CICU) following cardiac surgery. Nutritional status (malnutrition defined as weight for agez-score  <  − 2) and validated organ dysfunction scores (pSOFA and PELOD-2) on CICU days 1 and 3 were collected. The cohort included 967 patients with a median age of 2.8 years (IQR 0.46, 7.12) and hospital survival of 98.86%. The prevalence of malnutrition was 18.5% (n = 179). By multivariable logistic regression analysis including age, malnutrition, cardiopulmonary bypass time, and duration of mechanical ventilation; High STAT category (OR 7.51 [1.03–54],p = 0.0462) and PSOFA score >  5 day 1 (OR 1.84 [1.25–2.72],p = 0.0021) were associated with mortality; in a similar model including the same variables; High STAT category (OR 9.12 [1.33–62],p = 0.0243) and PELOD-2 score >  5 day 1 (OR 1.75 [1.10–2.77],p = 0.0175) were associated with mortality. Malnutrition was associated with persistent or worsening organ dysfunction by pSOFA (p <  0.05) and PELOD-2 (p <  0.01) on day 3....
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research