Protein Aggregation as a Protective Mechanism

One of the distinguishing features of old tissues is the presence of solid protein aggregrates. In some cases these are clearly linked to the pathology of specific diseases, such as Alzheimer's or forms of amyloidosis. For others no clear association with age-related dysfunction has yet been found. It seems prudent to develop means to remove these aggregates regardless, and this is one of the pillars of the SENS approach to rejuvenation treatments. In this paper, researchers propose that not all aggregates are equal, and some are the result of protective mechanisms that sequester an excess of proteins created through age-related dysfunction, rather than being a form of damage in and of themselves: Researchers used the tiny nematode worm Caenorhabditis elegans as a model organism to analyse the changes that occur in the proteome (the entirety of all proteins) during a lifespan. "The study is the most extensive of its kind in a whole organism quantifying more than 5,000 different proteins at multiple time points during aging." The researchers were able to show that the proteome undergoes extensive changes as the worms age. About one third of the quantified proteins significantly change in abundance. The normal relation between different proteins, which is critical for proper cell function, is lost. This shift overwhelms the machinery of protein quality control and impairs the functionality of the proteins. This is reflected in the widespread aggregation of surplus proteins ult...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs