Antiviral and antibacterial properties of phloroglucinols: a review on naturally occurring and (semi)synthetic derivatives with potential therapeutic interest

Crit Rev Biotechnol. 2023 Jan 2:1-18. doi: 10.1080/07388551.2022.2160695. Online ahead of print.ABSTRACTPhloroglucinol and derived compounds comprise a huge class of secondary metabolites widely distributed in plants and brown algae. A vast array of biological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer has been associated to this class of compounds. In this review, the available data on the antiviral and antibacterial capacity of phloroglucinols have been analyzed. Some of these compounds and derivatives show important antimicrobial properties in vitro. Phloroglucinols have been shown to be effective against viruses, such as human immunodeficiency virus (HIV), herpes or enterovirus, and preliminary data through docking analysis suggest that they can be effective against SARS-CoV-19. Also, some phloroglucinols derivatives have shown antibacterial effects against diverse bacteria strains, including Bacillus subtilis and Staphylococcus aureus, and (semi)synthetic development of novel compounds have led to phloroglucinols with a significantly increased biological activity. However, therapeutic use of these compounds is hindered by the absence of in vivo studies and scarcity of information on their mechanisms of action, and hence further research efforts are required. On the basis of this consideration, our work aims to gather data regarding the efficacy of natural-occurring and synthetic phloroglucinol derivatives as antiviral and antibact...

Source: Herpes - January 2, 2023 Category: Infectious Diseases Authors: Gregorio Peron Alice M L ópez Paulina Cabada-Aquirre Karen D Garay Buenrosto Keila C Ostos Mendoza Gail B Mahady Veronique Seidel Oksana Sytar Niranjan Koirala Roshani Gurung Zenisha Acharya Sundar Adhikari Antoni Sureda Miquel Martorell Javad Sharifi-Ra Source Type: research