Anti-tumor potential of nitroxyl derivative Pirolin in the DMBA-induced rat mammary carcinoma model: A comparison with quercetin.

CONCLUSION: The attenuation of tumor progression by Pirolin was comparable with the action of quercetin. No negative changes were observed in the heart of animals after Pirolin treatment. Thus, its use in targeting deregulated redox pathways should be further studied.
PMID: 25933965 [PubMed - in process]

Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Tabaczar S, Domeradzka K, Czepas J, Piasecka-Zelga J, Stetkiewicz J, Gwoździński K, Koceva-Chyła A Tags: Pharmacol Rep Source Type: research