The Association between Helicobacter pylori and Colorectal Neoplasia

Objectives: Both Helicobacter pylori (H. pylori) and colorectal neoplasia (CRN) are frequent entities in gastroenterology. Epidemiological data suggest an association between H. pylori positivity (H. pylori +) and CRN, whereas pathophysiologic considerations substantiate a possible causal relationship. However, the relationship between CRN and H. pylori+ may also be mediated by shared risk factors. Therefore, the aim of this cross-sectional study was to evaluate a possible independent relationship between H.pylori and CRN in a Central European cohort. Methods: We included 5,707 asymptomatic patients in this study. All patients underwent screening colonoscopy and upper gastrointestinal endoscopy. We assessed the association between any and advanced CRN and H. pylori + using multilevel logistic regression. We adjusted for age, sex, a positive family history of colorectal cancer and cardiovascular risk. Results: 1,082 patients (19%) were H. pylori + and 4,625 (81%) H. pylori -. Both patients with CRN and H. pylori had more cardiometabolic risk factors. In both univariate (aOR 1.20 1.10-1.31; p
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research