The new insight into the inflammatory response following focused ultrasound-mediated blood –brain barrier disruption

ConclusionsOur findings propose that a well-defined BBBD parameter of 0.25  MPa could ensure the safety without cellular/tissue damage or sterile inflammatory response in the brain. Furthermore, the fact that the excessive sonication parameters at 0.42 MPa could induce a sterile inflammation response via glial activation suggested the possibility that could lead to tissu e repair toward the homeostasis of the brain microenvironment through A2-type reactive astrocytes.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research