Chronic Chromatin Activation in Aged Muscle Stem Cells

In this study, we examined the chromatin accessibility changes of SCs, from quiescence exit, early activation, and regeneration, showing the trajectory of chromatin environment changes for SC activation in young and aged conditions. We showed that the chromatin environment of SCs is very compact during quiescence, becomes highly accessible on early activation, and gradually re-establish the compact state after long-term regeneration. We found that the old SCs exhibit a much more open chromatin environment, suggesting that the old SCs exhibit a chronically activated chromatin state. Link: https://doi.org/10.1016/j.isci.2022.104954
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs