Cardiac injection of USSC boosts remuscularization of the infarcted heart by shaping the T-cell response

Regenerating the injured heart remains one of the most vexing challenges in cardiovascular medicine. Cell therapy has shown potential for treatment of myocardial infarction, but low cell retention so far has limited its success. Here we show that intramyocardial injection of highly apoptosis-resistant unrestricted somatic stem cells (USSC) into infarcted rat hearts resulted in an unprecedented thickening of the left ventricular wall with cTnT+/BrdU+ cardiomyocytes that was paralleled by progressively restored ejection fraction.

Source: Journal of Molecular and Cellular Cardiology - December 6, 2022 Category: Cytology Authors: Zhaoping Ding, Kezhe Tan, Christina Alter, Sebastian Temme, Pascal Bouvain, Christoph Owenier, Sebastian H änsch, Sebastian Wesselborg, Christoph Peter, Stefanie Weidtkamp-Peters, Ulrich Flögel, Jessica Schira-Heinen, Kai Stühler, Julia Hesse, Gesine K Source Type: research