Abstract P3-11-03: A randomized, phase 2 trial of preoperative MM-121 with paclitaxel in triple negative (TN) and hormone receptor (HR) positive, HER2-negative breast cancer

Conclusion: Although a potential signal of benefit from MM-121 was observed in the HR+ group, the same was not observed in the TN group, and overall the results are inconclusive. Biomarker analyses, including pharmacodynamics studies, are ongoing. The observed safety profile is consistent with the expected toxicities associated with ErbB inhibitors and weekly paclitaxel, and did not impact exposure or compliance on treatment.
Citation Format: Frankie A Holmes, Kristi J McIntyre, Ian E Krop, Cynthia R Osborne, John W Smith II, Manuel R Modiano, Manish Gupta, Leona B Downey, Rita Nanda, Mansoor N Saleh, Jonathan R Young, Kerry E Horgan, William Kubasek, Gavin MacBeath, Michael A Danso, Joyce A O'Shaughnessy. A randomized, phase 2 trial of preoperative MM-121 with paclitaxel in triple negative (TN) and hormone receptor (HR) positive, HER2-negative breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P3-11-03.

Source: Cancer Research - April 30, 2015 Category: Cancer & Oncology Authors: Holmes, F. A., McIntyre, K. J., Krop, I. E., Osborne, C. R., Smith II, J. W., Modiano, M. R., Gupta, M., Downey, L. B., Nanda, R., Saleh, M. N., Young, J. R., Horgan, K. E., Kubasek, W., MacBeath, G., Danso, M. A., O'Shaughnessy, J. A. Tags: Poster Session Abstracts Source Type: research