Neurovascular coupling in bone regeneration

Experimental & Molecular Medicine, Published online: 29 November 2022; doi:10.1038/s12276-022-00899-6Further exploration of the interactions between nerve cells and vascularization (blood vessel development into tissue) during bone repair could provide therapeutic targets for bone diseases, including osteoarthritis and bone cancer. Seungyoung Lee at Incheon National University (Incheon, South Korea), Aaron James at Johns Hopkins School of Medicine (Baltimore, USA), and co-workers reviewed the roles of peripheral nerve cell groups and blood vessels in the regulation of bone remodeling. The growth of peripheral nerves and blood vessels is coordinated and functionally interdependent during skeletal development and repair. The density of nerve growth increases during bone remodeling, closely followed by increased vascularization. Inhibiting nerve signaling delays healing following a bone fracture. Two families of growth factor proteins, one expressed by sensory nerves and the other involved in triggering vascularization, could play key roles in this interaction between nerves and blood vessels.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research