MUC16 mutation is associated with tumor grade, clinical features, and prognosis in glioma patients

Gliomas are tumors derived from glial cells and glial precursor cells and one of the most frequent and malignant tumors among the primary adult brain tumors [1]. Low-grade gliomas (LGG) englobe slow-growing tumors that were classified by WHO (World Health Organization) in 2007 as grade 1 or 2 (diffuse gliomas) [2] or 3 (anaplastic astrocytomas) [3]. Grade 1 applied to tumors with a low proliferative rate that can potentially be cured following surgical resection. Grade 2 neoplasms were generally infiltrative despite having a low-level proliferative rate.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research