Preserved Ratio Impaired Spirometry in Relation to Cardiovascular Outcomes: A Large Prospective Cohort Study

Chest. 2022 Nov 10:S0012-3692(22)04064-8. doi: 10.1016/j.chest.2022.11.003. Online ahead of print.ABSTRACTBACKGROUND: Preserved ratio impaired spirometry (PRISm) is a heterogeneous condition characterized by a normal forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio with underlying impairment of pulmonary function. Data relating to the association of baseline and trajectories of PRISm with diverse cardiovascular outcomes is sparse.RESEARCH QUESTION: How do baseline and trajectories of PRISm impact subsequent cardiovascular events?STUDY DESIGN AND METHODS: In the UK Biobank cohort study, we included cardiovascular disease (CVD) free participants with spirometry (FEV1 and FVC values) at baseline (2006-2010). Participants with baseline spirometry and follow-up spirometry (2014-2020) were included in the lung function trajectory analysis. Cox proportional hazards multivariable regression was performed to evaluate the outcomes of major adverse cardiovascular events (MACE), incident myocardial infarction (MI), stroke, heart failure (HF), and CVD mortality in association with lung function.RESULTS: For baseline analysis (329,954 participants), the multivariable adjusted hazard ratios (HR) for participants had PRISm (vs. normal spirometry) were 1.26 (95% confidence interval (CI) 1.17-1.35) for MACE, 1.12 (1.01-1.25) for MI, 1.88 (1.72-2.05) for HF, 1.26 (1.13-1.40) for stroke, and 1.55 (1.37-1.76) for CVD mortality, respectively. A total of 22,781 participants ...
Source: Chest - Category: Respiratory Medicine Authors: Source Type: research