Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases

Ageing Res Rev. 2022 Nov 9:101785. doi: 10.1016/j.arr.2022.101785. Online ahead of print.ABSTRACTAge-related diseases have become more common with the advancing age of the worldwide population. Such diseases involve multiple organs, with tissue degeneration and cellular apoptosis. To date, there is a general lack of effective drugs for treatment of most age-related diseases and there is therefore an urgent need to identify novel drug targets for improved treatment. Acid-sensing ion channel 1a (ASIC1a) is a degenerin/epithelial sodium channel family member, which is activated in an acidic environment to regulate pathophysiological processes such as acidosis, inflammation, hypoxia, and ischemia. A large body of evidence suggests that ASIC1a plays an important role in the development of age-related diseases (e.g., stroke, rheumatoid arthritis, Huntington's disease, and Parkinson's disease.). Herein we present: 1) a review of ASIC1a channel properties, distribution, and physiological function; 2) a summary of the pharmacological properties of ASIC1a; 3) and a consideration of ASIC1a as a potential therapeutic target for treatment of age-related disease.PMID:36371015 | DOI:10.1016/j.arr.2022.101785
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Source Type: research