Global SARS-CoV-2 seroprevalence from January 2020 to April 2022: A systematic review and meta-analysis of standardized population-based studies

by Isabel Bergeri, Mairead G. Whelan, Harriet Ware, Lorenzo Subissi, Anthony Nardone, Hannah C. Lewis, Zihan Li, Xiaomeng Ma, Marta Valenciano, Brianna Cheng, Lubna Al Ariqi, Arash Rashidian, Joseph Okeibunor, Tasnim Azim, Pushpa Wijesinghe, Linh-Vi Le, Aisling Vaughan, Richard Pebody, Andrea Vicari, Tingting Yan, Mercedes Yanes-Lane, Christian Cao, David A. Clifton, Matthew P. Cheng, Jesse Papenburg, David Buckeridge, Niklas Bobrovitz, Rahul K. Arora, Maria D. Van Kerkhove, Unity Studies Collaborator Group BackgroundOur understanding of the global scale of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection remains incomplete: Routine surveillance data underestimate infection and cannot infer on population immunity; there is a predominance of asymptomatic infections, and uneven access to diagnostics. We meta-analyzed SARS-CoV-2 seroprevalence studies, standardized to those described in the World Health Organization ’s Unity protocol (WHO Unity) for general population seroepidemiological studies, to estimate the extent of population infection and seropositivity to the virus 2 years into the pandemic. Methods and findingsWe conducted a systematic review and meta-analysis, searching MEDLINE, Embase, Web of Science, preprints, and grey literature for SARS-CoV-2 seroprevalence published between January 1, 2020 and May 20, 2022. The review protocol is registered with PROSPERO (CRD42020183634). We included general population cross-sectional and cohort studies m...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research