Climbing mountains: “I won’t let ulcerative colitis define me”

Mark Donohue craves outdoor activity. While most were braving Old Man Winter’s 2015 wrath, this 19-year-old Ticonderoga, New York native embraced Mother Nature and hiked to the summit of his home state’s Black Mountain, tackled the slopes in Colorado and pond-skated locally with friends. Mark says his love of the great outdoors and his quest to climb new personal heights has never been overshadowed by ulcerative colitis. “I won’t let the disease define me,” says Donohue, a college freshman at Binghamton University in New York. “I take it in stride, stay positive and don’t let ulcerative colitis dictate the kind of person I want to be.” Ulcerative colitis isn’t slowing Mark Donohue down. Watch Mark’s amateur video recapping his 2015 winter adventures. Mark’s journey with Inflammatory Bowel Disease (IBD) began in 2010 during his freshman year of high school. The 14-year-old embraced high school life – he joined the football team, enrolled in the school’s music program and formed a student-run band called “Flipside.” He was thriving.   A season of change Mark’s quest for new adventures continued. Later in the year, the young athlete played winter basketball and spring baseball.  As the seasons changed and Mark’s activity list lengthened, one thing remained constant: his ongoing stomach pain. “I had a lot of stomach pain and cramps, but that was pretty typi...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & conditions Our patients’ stories Source Type: news

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CONCLUSIONS: The effects of antibiotics, probiotics and other interventions for treating and preventing pouchitis are uncertain. Well designed, adequately powered studies are needed to determine the optimal therapy for the treatment and prevention of pouchitis. PMID: 31136680 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
AbstractStrongyloides stercoralis (S. stercoralis), a human intestinal nematode, can lead to hyper/disseminated (HD) infection in patients treated with corticosteroids. Here, we report a case of strongyloidiasis in a 58-year-old female with a history of rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). The patient presented with abdominal pain and gastrointestinal (GI) bleeding. Stool was negative for parasitic agents in the first direct smear examination, and the patient with the probable diagnosis ofHelicobacter pylori (H. pylori) infection or Crohn ’s disease received antibiotics and corticosteroids. ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
In this study, we evaluated the effect of auranofin on the radiosensitivity of intestinal epithelial cells. The treatment with a combination of 1 μM auranofin and 5 Gy ionizing radiation showed clear additive effects on caspase 3 cleavage and apoptotic DNA fragmentation in IEC-6 cells, and auranofin administration significantly aggravated the radiation-induced intestinal injury in mice. Auranofin treatment also resulted in the activation of the unfolded protein response and in the inhibition of thioredoxin reductase, which is a key component of the cellular antioxidant system. Pre-treatment with N-acetyl cysteine, a wel...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This report describes 2 rare cases of duodenal mucosa lesions in patients with UC after total colectomy. Patient concerns: In case 1, a patient of 45-year-old with intermittent diarrhea and bloody mucosanguineous feces who was diagnosed as UC, revealed diffuse erosive ulcers in the descending duodenum through gastroscopy after total colectomy. In case 2, a 55-year-old Chinese female with UC, aggravated to colon cancer and received total colectomy. Eighteen months after surgery, the patient was admitted to hospital following upper abdominal pain and acid regurgitation. A gastroscopy found inflammation in the descending p...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
We report two cases of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) that were initially considered to be ulcerative colitis (UC) and lymphocytic colitis, respectively. Both patients presented with diarrhea and abdominal pain. Colonoscopy revealed hyperemia and scattered shallow ulcerations in the colon, without obvious mass. Microscopically, the first case exhibited features of active chronic colitis. The second case exhibited features mimicking lymphocytic colitis and ileitis. Correct diagnosis of lymphoma was established when the cases were received as consultation, with additional ancillary tests perfo...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
Conclusions:The syndrome of IBS affects the sleep quality of IBD in clinical remission, especially in CD. Its additive effect with IBD may worsen symptoms that correlated with sleep disturbance, such as pain, psychological and physical condition, and QOL.Keywords:In flammatory bowel diseases, irritable bowel syndrome, quality of life, sleep
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
TUESDAY, Jan. 22, 2019 -- Ulcerative colitis is a chronic inflammatory bowel disease triggering pain and bloody stools, and it can raise the odds for colon cancer. But now, research suggests that fecal transplants -- basically, delivering a healthy...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
This holiday season we are all in search of the perfect gift. What is the one thing you truly desire for yourself and your family? Don’t you think we all want it? What if you were handed a beautifully wrapped box containing a miraculous tool that caused dramatic weight loss without limiting calories or requiring exercise? What if this gift reduced appetite, shrunk belly fat, dropped your dress size into the single digits, and accomplished all of this while sparing you from a Biggest Loser sob fest? What if that same gift freed you from acid reflux, heartburn, bowel urgency, and diarrhea, but also improved mood, incre...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Dr. Davis Gliadin gluten gluten-free grain-free grains wheat belly Source Type: blogs
Conclusion :HL can emerge in IBD patients on immunosuppressive therapy and physicians must be aware of this possibility. EBV infection might have an intermediate role between immunosuppressive treatment and lymphoma. Those data should alert clinicians that, not only thiopurine use but also the disease itself could contribute to a higher occurrence of lymphoproliferative disorders.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma-Clinical Studies Source Type: research
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