Centrophenoxine Is Not That Interesting

The Forever Healthy Foundation publishes, intermittently, a series of rigorous literature reviews for presently available treatments that are alleged to help with mechanisms of aging. The viewpoint is conservative; the authors are less convinced by the evidence for the utility of early senolytics than I am, for example. Their latest publication covers centrophenoxine, not a treatment I am familiar with, but by the sound of it I'm not missing out on anything. The data is emblematic of much of what is marketed under the "anti-aging" banner; unconvincing, mixed, marginal. Centrophenoxine (CPH) is a compound consisting of dimethylaminoethanol (DMAE) and para-chlorophenoxyacetic acid (pCPA), joined by a chemical bond. DMAE can be converted by cells into choline, which is a precursor of membrane phospholipids, neurotransmitters, and other important biomolecules. The pCPA component enhances the penetration of CPH across the blood-brain barrier. CPH supplementation is hypothesized to increase brain acetylcholine levels, protect neurons from oxidative damage, improve cognitive function, and reduce age-related lipofuscin accumulation. There is moderate evidence that centrophenoxine may benefit patients hospitalized for injury to the brain from either vascular or traumatic origin, especially in acute cerebral hemorrhage. However, despite several decades of use since it was first synthesized, the clinical utility of centrophenoxine in healthy individuals remains unclear, ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs