Tripartite Motif Containing 26 is a Positive Predictor for Endometrial Carcinoma Patients and Regulates Cell Survival in Endometrial Carcinoma
Horm Metab Res DOI: 10.1055/a-1926-7364Functioning as an E3 ubiquitin ligase, tripartite motif containing 26 (TRIM26)
can regulate the tumor behavior and the relevant inflammatory immune response.
Endometrial carcinoma is a major gynecological malignant tumor in the world,
while no relevant research has been performed. KMplot, a web-based survival
analysis tool, demonstrated that TRIM26 expression was positively correlated
with the overall survival in gynecological tumors, such as ovarian, cervical,
and endometrial cancer. The relatively low expression of TRIM26 was also found
in endometrial cancer tissues and endometrial cancer cell lines. In the online
Gene Expression Profiling Interactive Analysis (GEPIA) platform, TRIM26 was
positively correlated with the pre-apoptosis genes of p53, BIM, BID, BAX, and
BAK, and negatively correlated with the anti-apoptosis gene of BCLW. To further
explore the function of TRIM26 in endometrial carcinoma, Ishikawa and KLE cells
were infected with PLVX-TRIM26-derived lentivirus. TRIM26 overexpression
suppressed the growth of endometrial cells, with downregulated p-AKT and
upregulated BIM and BID expression. PLVX-TRIM26 overexpressed Ishikawa cells
were injected subcutaneously into the side flanks of male BALB/C nude
mice to construct a TRIM26-overexpression xenograft model. TRIM26 over...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Lu, Tanmin Wu, Yu Tags: Original Article: Endocrine Research Source Type: research
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