A rare case of Pseudomonas aeruginosa enteritis induced by pembrolizumab

A 72-year-old male had pseudomonal enteritis related to pembrolizumab. Chemotherapy for hypopharyngeal carcinoma with lung metastasis comprised cisplatin, 5-FU, and pembrolizumab. On day 14 of chemotherapy treatment he had a sudden prominent abdominal bulge, decreased consciousness, and drop in blood pressure in septic shock. CT scan showed marked intestinal gas through to intrahepatic bile ducts. Pseudomonas aeruginosa was simultaneously detected in both blood and stool cultures. Intestinal endoscopy revealed ulcerative lesions from the transverse colon to the rectum.

Source: Auris, Nasus, Larynx - September 14, 2022 Category: ENT & OMF Authors: Mai Miyamoto, Shunji Tamagawa, Masamitsu Kono, Masayoshi Hijiya, Takuro Iyo, Tetsuya Kinoshita, Tatsuya Shiga, Katsuya Okuda, Taku Fujishiro, Masaki Ueno, Yuki Mizumoto, Fumiyoshi Kojima, Makiko Ohtani, Shin-ichi Murata, Hiroki Yamaue, Muneki Hotomi Tags: Case report Source Type: research