IJERPH, Vol. 19, Pages 11422: Coronavirus Vaccination: Spike Antibody Levels in Health Workers after Six Months & mdash;A Cross-Sectional Study

IJERPH, Vol. 19, Pages 11422: Coronavirus Vaccination: Spike Antibody Levels in Health Workers after Six Months—A Cross-Sectional Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph191811422 Authors: Lukas Damerau Georg Mühlenbruch Agnes Evenschor-Ascheid Christine Fussen Albert Nienhaus Claudia Terschüren Robert Herold Volker Harth Healthcare workers bear a high risk of infection during epidemics and pandemics such as the current SARS-CoV-2 pandemic. Various new vaccines have been approved. We investigated the influence of the time elapsed since vaccination, as well as of vaccination schema, on health workers’ spike antibody levels following their second vaccination. Blood samples were obtained from employees working at a German hospital between August 2021 and December 2021 on average half a year (range 130–280 days) after their second vaccination. Levels of SARS-CoV-2-IgG antibodies (spike and nucleocapsid protein) were qualitatively detected via chemiluminescent immunoassays (CLIAs). A previous infection with SARS-CoV-2 was an exclusion criterion. In total, 545 persons were included in this cross-sectional study. Most participants (97.8%) showed elevated anti-spike concentrations. Anti-spike levels differed significantly among vaccination schemas. Repeated vector vaccinations resulted in lower protective antibody levels. Higher age levels, immunosuppression and a longer t...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research