APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett's-associated esophageal adenocarcinomas

CONCLUSION: Our findings established a novel function of APE1 in EAC progression elucidating druggable molecular vulnerabilities via targeting APE1 or YAP1 for the treatment of EAC.PMID:36045416 | DOI:10.1186/s13046-022-02472-5

Source: Clin Med Res - August 31, 2022 Category: Research Authors: Farah Ballout Heng Lu Lei Chen Kannappan Sriramajayam Jianwen Que Zhipeng Meng Timothy C Wang Silvia Giordano Alexander Zaika Oliver McDonald Dunfa Peng Wael El-Rifai Source Type: research