Evaluation of the Effect of Uridine Diphosphate-Glucuronosyltransferases (UGT) Inhibition by Valproic Acid on Vixotrigine Pharmacokinetics in Healthy Volunteers

ConclusionsValproic acid, a uridine diphosphate-glucuronosyltransferase inhibitor, significantly increased vixotrigine systemic exposure.Clinical Trial RegistrationClinicalTrials.gov Identifier: NCT03385525.

http://link.springer.com/10.1007/s40261-022-01194-y

Source: Clinical Drug Investigation - August 31, 2022 Category: Drugs & Pharmacology Source Type: research