Molecules, Vol. 27, Pages 5628: Effects of Lycium barbarum L. Polysaccharides on Vascular Retinopathy: An Insight Review

Molecules, Vol. 27, Pages 5628: Effects of Lycium barbarum L. Polysaccharides on Vascular Retinopathy: An Insight Review Molecules doi: 10.3390/molecules27175628 Authors: Chunhong Yang Qi Zhao Shiling Li Lili Pu Liqiong Yu Yaqin Liu Xianrong Lai Vascular retinopathy is a pathological change in the retina caused by ocular or systemic vascular diseases that can lead to blurred vision and the risk of blindness. Lycium barbarum polysaccharides (LBPs) are extracted from the fruit of traditional Chinese medicine, L. barbarum. They have strong biological activities, including immune regulation, antioxidation, and neuroprotection, and have been shown to improve vision in numerous studies. At present, there is no systematic literature review of LBPs on vascular retinal prevention and treatment. We review the structural characterization and extraction methods of LBPs, focus on the mechanism and pharmacokinetics of LBPs in improving vascular retinopathy, and discuss the future clinical application and lack of work. LBPs are involved in the regulation of VEGF, Rho/ROCK, PI3K/Akt/mTOR, Nrf2/HO-1, AGEs/RAGE signaling pathways, which can alleviate the occurrence and development of vascular retinal diseases in an inflammatory response, oxidative stress, apoptosis, autophagy, and neuroprotection. LBPs are mainly absorbed by the small intestine and stomach and excreted through urine and feces. Their low bioavailability in vivo has led to the development of novel dosage form...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research