Lower disease activity but higher risk of severe COVID-19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN- α

CONCLUSION: The production of non-neutralising and neutralising anti-IFN-I antibodies in SLE is likely to be a consequence of SLE-associated high IFN-I serum levels, with a beneficial effect on disease activity, yet a greater viral risk. This finding reinforces the recommendations for vaccination against SARS-CoV-2 in SLE.PMID:35973806 | DOI:10.1136/ard-2022-222549

Source: Herpes - August 16, 2022 Category: Infectious Diseases Authors: Alexis Mathian Paul Breillat Karim Dorgham Paul Bastard Caroline Charre Raphael Lhote Paul Quentric Quentin Moyon Alice-Andr ée Mariaggi Suzanne Mouries-Martin Clara Mellot Fran çois Anna Julien Haroche Fleur Cohen-Aubart Delphine Sterlin No ël Zahr Ad Source Type: research