Altered Circulating Leptin, hGH, and IGF-I in Prediabetes and Screening-Diagnosed T2DM Unrelated to Metabolic Syndrome in Women Post Gestational Diabetes
Horm Metab Res DOI: 10.1055/a-1850-5392Recently, we proposed two pathophysiologic subtypes of type 2 diabetes mellitus
(T2DM), one related and one unrelated to metabolic syndrome. To begin to
understand the pathophysiology of the subtype unrelated to metabolic syndrome,
we now measured selected hormones and signaling molecules in affected
individuals. In this cross-sectional analysis, we examined 138 women out of the
monocenter, post gestational diabetes study PPSDiab. Of these women, 73 had
prediabetes or screening-diagnosed T2DM, 40 related to metabolic syndrome and 33
unrelated. The remaining 65 women were normoglycemic controls. Our analysis
included medical history, anthropometrics, oral glucose tolerance testing,
laboratory chemistry, and cardiopulmonary exercise testing. In addition, plasma
proinsulin/insulin ratio, growth hormone (hGH) nadir during oral glucose
tolerance testing, Insulin-like Growth Factor I (IGF-I), Leptin, Resistin,
Adiponectin, Fetuin-a, FGF21, and myostatin were measured. Compared to controls,
women with prediabetes or screening-diagnosed T2DM unrelated to metabolic
syndrome depicted higher plasma Leptin [10.47(6.6–14.57) vs.
5.52(3.15–10.02); p<0.0001] and IGF-I
[193.01(171.00–213.30) vs. 167.97(138.77–200.64);
p=0.0008], as well as a lower hGH nadir [0.07(0.05–0.15)...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Kern-Matschilles, Stefanie Gar, Christina Schilbach, Katharina Haschka, Stefanie Julia Rauch, Miss Barbara Then, Cornelia Seissler, Jochen Bidlingmaier, Martin Lechner, Andreas Tags: Original Article: Endocrine Care Source Type: research
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