A Novel ATM Antisense Transcript ATM-AS Positively Regulates ATM Expression in Normal and Breast Cancer Cells

ConclusionThe present study demonstrated that ATM-AS, an antisense transcript located within theATM gene body, is an essential positive regulator of ATM expression, and functions by mediating the binding of KAT5 to theATM promoter. These findings uncover the novel mechanism underlying the dysregulation of theATM gene in breast cancer, and enrich our understanding of how an antisense transcript regulates its host gene.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - Category: Research Source Type: research