An Ultrasound ‐Responsive Theranostic Cyclodextrin‐Loaded Nanoparticle for Multimodal Imaging and Therapy for Atherosclerosis
This study reports CD delivery via air-trapped polybutylcyanoacrylate nanoparticles (with diameters of 388 ± 34 nm) loaded with CD (CDNPs). The multimodal contrast ability of these nanoparticles after being loaded with IR780 dye in mice is demonstrated using ultrasound and near-infrared imaging. It is shown that CDNPs enhance the cellular uptake of CD in murine cells. In an ApoE–/– mouse model of atherosclerosis, treatment with CDNPs significantly improves the anti-atherosclerotic efficacy of CD. Ultrasound triggering further improves CD uptake, highlighting that CDNPs can be used for ultrasound imaging and ultrasound-responsive CD delivery. Thus, CDNPs represent a theranostic nanocarrier for potential application in patients with atherosclerosis.
Source: Small - Category: Nanotechnology Authors: Sourabh Mehta,
Viktoria Bongcaron,
Tien K Nguyen,
Yugandhara Jirwanka,
Ana Maluenda,
Aidan P G Walsh,
Jathushan Palasubramaniam,
Mark D Hulett,
Rohit Srivastava,
Alex Bobik,
Xiaowei Wang,
Karlheinz Peter Tags: Research Article Source Type: research
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