Liver, NAFLD and COVID-19
Horm Metab Res DOI: 10.1055/a-1834-9008Coronavirus disease 2019 (COVID-19) is characterized by a wide clinical spectrum
that includes abnormalities in liver function indicative of liver damage.
Conversely, people with liver diseases are at higher risk of severe COVID-19. In
the current review, we summarize first the epidemiologic evidence describing the
bidirectional relationship between COVID-19 and liver function/liver
diseases. Additionally, we present the most frequent histologic findings as well
as the most important direct and indirect mechanisms supporting a COVID-19
mediated liver injury. Furthermore, we focus on the most frequent liver disease
in the general population, non-alcoholic or metabolic-associated fatty liver
disease (NAFLD/MAFLD), and describe how COVID-19 may affect
NAFLD/MAFLD development and progression and conversely how
NAFLD/MAFLD may further aggravate a COVID-19 infection. Finally, we
present the long-term consequences of the pandemic on the development and
management of NAFLD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Hoffmann, Carlotta Gerber, Philipp A. Cavelti-Weder, Claudia Licht, Louisa Kotb, Reham Al Dweik, Rania Cherfane, Michele Bornstein, Stefan Perakakis, Nikolaos Tags: Review Source Type: research