Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations

ConclusionsWe confirmed the causal effects of 10 cardiometabolic traits on CAD and identified causal risk effects of RBC, hemoglobin, hematocrit, and UA independent of traditional cardiometabolic factors. We found no causal effects for 23 clinical factors, despite their reported epidemiological associations. Our findings suggest the physiology of red blood cells and the level of UA as potential intervention targets for the prevention of CAD.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research