Latest Phase 3 Data for First-in-Class TREMFYA ® (guselkumab) Demonstrates Significant and Durable Improvement in Signs and Symptoms of Active Psoriatic Arthritis while Maintaining its Safety Profile in Patients with Inadequate Response to Tumor Necrosis Factor Inhibition (TNFi-IR)
SPRING HOUSE, PENNSYLVANIA, December 3, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new TREMFYA® (guselkumab) efficacy and safety data from the Phase 3b COSMOS trial published in Annals of the Rheumatic Diseases (ARD), evaluating this selective interleukin (IL)-23 inhibitor in adults with active psoriatic arthritis (PsA) who demonstrated inadequate efficacy or intolerance to tumor necrosis factor inhibition (TNFi).1 Results showed significantly higher proportions of patients treated with TREMFYA had improvement in joint signs and symptoms and complete skin clearance versus placeb...
Source: Johnson and Johnson - December 3, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial
Conclusions: The use of systemic metronidazole as an adjunct to non-surgical treatment of peri-implantitis resulted in significant additional improvements in clinical, radiographic, and microbiological parameters after 12 months of follow-up. This study is registered in ClinicalTrials.gov (NCT03564301). (Source: Dental Technology Blog)
Source: Dental Technology Blog - November 30, 2021 Category: Dentistry Source Type: news
CDC: E. Coli Outbreak Linked To Baby Spinach, Across 7 States
So far this outbreak has left at least 10 people ill and two hospitalized. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - November 20, 2021 Category: Pharmaceuticals Authors: Bruce Y. Lee, Senior Contributor Tags: Healthcare /healthcare Innovation /innovation Business /business Food & Drink /food-drink pharma Source Type: news
Poorer nations still lack access to world ’s key antibiotics
Only 54 of 166 assessed treatments have policies aiding use by low-income countries, says non-profit groupThe world ’s biggest drugs makers have pressed on in the fight against superbugs despite the pandemic, but millions of people in poorer countries, where the risk of drug-resistant infections is highest, are still missing out on key antibiotics.A report from the Access to Medicine Foundation, an Amsterdam-based non-profit group, shows that only 54 of 166 medicines and vaccines assessed are covered by an access strategy to make them available to low- and middle-income countries.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - November 18, 2021 Category: Science Authors: Julia Kollewe Tags: Pharmaceuticals industry Vaccines and immunisation Tuberculosis E coli Gonorrhoea World Health Organization Business Drug resistance Drugs Drugs policy Medical research Global development Science Netherlands World news Source Type: news
Janssen Reports Positive Topline Week 48 Phase 2 Results for TREMFYA ® (guselkumab) in Adults With Moderately to Severely Active Crohn's Disease
SPRING HOUSE, PENNSYLVANIA, November 17, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced topline results from the Phase 2 GALAXI 1 clinical trial which showed rates of clinical remission (Crohn’s Disease Activity Index [CDAI]<150) previously reported at week 12 increased at week 48 among adults with moderately to severely active Crohn’s disease (CD) treated with TREMFYA® (guselkumab).1 At week 48, 65 percent of patients receiving TREMFYA achieved clinical remission. TREMFYA is under investigation and not currently approved for the treatment of CD in the U.S.2Janssen previously...
Source: Johnson and Johnson - November 17, 2021 Category: Pharmaceuticals Source Type: news
Does high adherence to contact precautions lead to low in-hospital transmission of multidrug-resistant microorganisms in the endemic setting? "
Conclusion: High adherence coupled with continuous monitoring of CP correlated to a very low in-hospital transmission rate. These results indicate that CP is highly effective if routine monitoring of adherence is implemented. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news
New Comprehensive Phase 3 Data Show First-in-Class TREMFYA ® (guselkumab) Provided Durable Improvements in Measures of Psoriatic Arthritis (PsA) Disease Activity Through Two Years
SPRING HOUSE, PENNSYLVANIA, November 1, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced comprehensive efficacy and safety data from the DISCOVER–2 trial of TREMFYA® (guselkumab) were published in Arthritis & Rheumatology, representing the final results of the first two-year clinical trial investigating a selective interleukin (IL)-23 inhibitor therapy in active psoriatic arthritis (PsA).1 Results show a majority of TREMFYA-treated biologic-naïve adult patients with active PsA achieved improvements in joint signs and symptoms (American College of Rheumatology [ACR] 20/50/70)a a...
Source: Johnson and Johnson - November 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
What Causes Irritability?
Discussion
Child abuse or non-accidental trauma is a clinical diagnosis. It is the constellation of history, physical examination, radiographic evaluation, laboratory testing and investigation that determines if child abuse has occurred. Irritability caused by fractures or other trauma can be a presenting symptom of abuse. Fractures can be a presentation but they are also common problems not associated with abuse. Femoral shaft fractures are estimated to account for only 1.6% of all fractures in children, therefore they are potentially more suspicious for child abuse. A review of femur fractures can be found here. A review...
Source: PediatricEducation.org - October 18, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Does high adherence to contact precautions lead to low in-hospital transmission of multi-drug-resistant micro-organisms in the endemic setting?
Conclusion: High adherence coupled with continuous monitoring of CPs correlated with a very low in-hospital transmission rate. These results indicate that CPs are highly effective if routine monitoring of adherence is implemented. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 15, 2021 Category: Consumer Health News Source Type: news
Spice pill to ease misery of cystitis
Researchers believe the combination of active ingredients will work together to prevent E. coli and other bacteria responsible for the infection sticking to the walls of the urinary tract. (Source: the Mail online | Health)
Source: the Mail online | Health - October 12, 2021 Category: Consumer Health News Source Type: news
A case of alimentary tract hemorrhage caused by Japanese red mushroom poisoning - Sun YY, Chen XR, Zhao GJ, Wu B, Lu ZQ.
This article retrospectively analyzes the clinical data of a patient with gastrointestinal bleeding caused by russula poisoning in the First Affili... (Source: SafetyLit)
Source: SafetyLit - October 11, 2021 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
E. coli scare: People in Oxted told to boil drinking water
SES Water says further tests are expected to confirm the scale of the potential contamination. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 8, 2021 Category: Consumer Health News Source Type: news
New Analysis Presented by Janssen at United European Gastroenterology Week (UEGW) Demonstrates Long-Term Safety Profile for STELARA ® (ustekinumab) in Older Patients Across Approved Indications
SPRING HOUSE, PENNSYLVANIA, October 4, 2021 – Today, the Janssen Pharmaceutical Companies of Johnson & Johnson announced a new analysis of STELARA® (ustekinumab) pooled safety data from 13 clinical studies across approved indications, showing rates of key safety events among adults 60 years and older treated with STELARA for up to five yearsa were similar to rates observed with placebo during the control phase of these trials.1,b Approved indications included adults with moderately to severely active Crohn’s disease (CD), moderately to severely active ulcerative colitis (UC), moderate to severe plaque psoriasis (P...
Source: Johnson and Johnson - October 4, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Mayo Clinic Minute: What to do if your child has a bellyache
Kids are back in the classroom, and a common back-to-school sickness is viral gastroenteritis, or stomach flu. It's an intestinal infection marked by watery diarrhea, abdominal cramps, nausea or vomiting, and sometimes fever. Watch: The Mayo Clinic Minute https://youtu.be/jwxQ2L4ZVXE Journalists: Broadcast-quality video (0:58) is in the downloads at the end of this post. Please "Courtesy: Mayo Clinic News Network." Read the script. If your child is showing symptoms of a stomach bug, such as vomiting… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - September 30, 2021 Category: Databases & Libraries Source Type: news
Pet Store Puppies Linked to Campylobacter Infections Pet Store Puppies Linked to Campylobacter Infections
Puppies can carry very drug-resistant Campylobacter. You might not want them licking your face.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 15, 2021 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
