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Pancytopenia Due to Folate Deficiency
J Assoc Physicians India. 2024 Jan;72(1):113. doi: 10.59556/japi.71.0443.ABSTRACTWe found the article on "The Digital Technology in Clinical Medicine: From Calculators to ChatGPT" interesting.1 According to Kulkarni et al., humanity has witnesses four important social system changes, starting with the primitive huntersgatherers and progressing to horticultural, agricultural, industrial, and the current fifth, which is based on digital information technology and has altered the way we present, recognize, and utilize different factors of production. In clinical medicine, digital technology has advanced significantly since th...
Source: Journal of the Association of Physicians of India - May 13, 2024 Category: General Medicine Authors: Somarajan Anandan Simi Soman Jyothish P Kumar Divine S Shajee Source Type: research

Digital Technology in Clinical Medicine: Correspondence
J Assoc Physicians India. 2024 Jan;72(1):112. doi: 10.59556/japi.71.0429.ABSTRACTWe found the article on "The Digital Technology in Clinical Medicine: From Calculators to ChatGPT" interesting.1 According to Kulkarni et al., humanity has witnesses four important social system changes, starting with the primitive huntersgatherers and progressing to horticultural, agricultural, industrial, and the current fifth, which is based on digital information technology and has altered the way we present, recognize, and utilize different factors of production. In clinical medicine, digital technology has advanced significantly since th...
Source: Journal of the Association of Physicians of India - May 13, 2024 Category: General Medicine Authors: Amnuay Kleebayoon Viroj Wiwanitkit Source Type: research

Commentary on "A review of new drugs approved by the food and drug administration in 2022"
J Family Med Prim Care. 2024 Mar;13(3):1133. doi: 10.4103/jfmpc.jfmpc_1833_23. Epub 2024 Apr 4.NO ABSTRACTPMID:38736795 | PMC:PMC11086780 | DOI:10.4103/jfmpc.jfmpc_1833_23 (Source: Primary Care)
Source: Primary Care - May 13, 2024 Category: Primary Care Authors: Kopal Sharma Amit Sharma Rupa Kapadia Source Type: research

Social Perceptions of Masculinity and Sexual Esteem Are Impacted by Viagra Use, Testosterone, and Sexual Performance
Arch Sex Behav. 2024 May 13. doi: 10.1007/s10508-024-02880-y. Online ahead of print.ABSTRACTSexual behaviors play a role in the social construction of masculinity. Moreover, this stereotype has been capitalized upon by pharmaceutical companies, as well as those that sell products not approved by the U.S. Food and Drug Administration, for purposes of marketing sexual medicines. Stereotypical notions of masculinity, however, also emphasize the importance of self-reliance, which may cause some to look unfavorably upon the use of sexual medicine. Consistent with this notion, a male target was viewed as more masculine when his ...
Source: Archives of Sexual Behavior - May 13, 2024 Category: Psychiatry & Psychology Authors: Wayne R Hawley Bryn A Cancilla Julia L Barnes Gregory D Morrow Source Type: research

Primary Care ’s Role in Prescribing Mail-Order Mifepristone
This Viewpoint discusses the controversy over mail-order mifepristone prescribed by primary care clinicians for first-trimester abortion as it relates to the history of initial approval, the Supreme Court case Alliance for Hippocratic Medicine v US Food and Drug Administration, and available clinical research. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - May 13, 2024 Category: Internal Medicine Source Type: research

Structure-Activity Relationship Analysis of Fluoxetine for Suppression of Inflammatory Cytokine Production
Biol Pharm Bull. 2024;47(5):946-954. doi: 10.1248/bpb.b24-00083.ABSTRACTThere is accumulating evidence that selective serotonin reuptake inhibitors (SSRIs), clinically used as antidepressants, have a beneficial effect on inflammatory diseases such as coronavirus disease 2019 (COVID-19). We previously compared the inhibitory effects of five U.S. Food and Drug Administration (FDA)-approved SSRIs on the production of an inflammatory cytokine, interleukin-6 (IL-6), and concluded that fluoxetine (FLX) showed the most potent anti-inflammatory activity. Here, we investigated the structure-activity relationship of FLX for anti-inf...
Source: Biological and Pharmaceutical Bulletin - May 12, 2024 Category: Drugs & Pharmacology Authors: Yohei Takenaka Ryu Tanaka Kazuki Kitabatake Fumiaki Uchiumi Shin Aoki Kouji Kuramochi Mitsutoshi Tsukimoto Source Type: research

Risk of Enzyme- and Transporter-Mediated Drug Interactions With Drugs Approved by the US Food and Drug Administration in 2022: A Detailed Analysis of In Vitro and Clinical Data Available in New Drug Application Reviews
Clin Ther. 2024 May 10:S0149-2918(24)00086-9. doi: 10.1016/j.clinthera.2024.04.008. Online ahead of print.ABSTRACTPURPOSE: This analysis aimed to provide mechanistic understanding and clinical relevance of pharmacokinetic drug-drug interactions (DDIs) associated with drugs approved by the Food and Drug Administration in 2022.METHODS: Drug metabolism, transport, and DDI data available in New Drug Applications (NDAs) of small molecular drugs approved (n = 22) was analyzed. The mechanism and clinical magnitude of these interactions were characterized based on in vitro, in silico, and clinical data.FINDINGS: As victims, 10 dru...
Source: Clinical Therapeutics - May 11, 2024 Category: Drugs & Pharmacology Authors: Jingjing Yu Yan Wang Isabelle Ragueneau-Majlessi Source Type: research

Genes, Vol. 15, Pages 614: Comorbidity-Guided Text Mining and Omics Pipeline to Identify Candidate Genes and Drugs for Alzheimer & rsquo;s Disease
Genes, Vol. 15, Pages 614: Comorbidity-Guided Text Mining and Omics Pipeline to Identify Candidate Genes and Drugs for Alzheimer’s Disease Genes doi: 10.3390/genes15050614 Authors: Iyappan Ramalakshmi Oviya Divya Sankar Sharanya Manoharan Archana Prabahar Kalpana Raja Alzheimer&rsquo;s disease (AD), a multifactorial neurodegenerative disorder, is prevalent among the elderly population. It is a complex trait with mutations in multiple genes. Although the US Food and Drug Administration (FDA) has approved a few drugs for AD treatment, a definitive cure remains elusive. Research efforts persi...
Source: Genes - May 11, 2024 Category: Genetics & Stem Cells Authors: Iyappan Ramalakshmi Oviya Divya Sankar Sharanya Manoharan Archana Prabahar Kalpana Raja Tags: Article Source Type: research

Recent advances and future directions on small molecule VEGFR inhibitors in oncological conditions
Eur J Med Chem. 2024 May 6;272:116472. doi: 10.1016/j.ejmech.2024.116472. Online ahead of print.ABSTRACT"A journey of mixed emotions" is a quote that best describes the progress chart of vascular endothelial growth factor receptor (VEGFR) inhibitors as cancer therapeutics in the last decade. Exhilarated with the Food and Drug Administration (FDA) approvals of numerous VEGFR inhibitors coupled with the annoyance of encountering the complications associated with their use, drug discovery enthusiasts are on their toes with an unswerving determination to enhance the rate of translation of VEGFR inhibitors from preclinical to c...
Source: European Journal of Medicinal Chemistry - May 10, 2024 Category: Chemistry Authors: Amandeep Thakur Mandeep Rana Anshul Mishra Charanjit Kaur Chun-Hsu Pan Kunal Nepali Source Type: research

Technologies for the discovery of G protein-coupled receptor-targeting biologics
Curr Opin Biotechnol. 2024 May 9;87:103138. doi: 10.1016/j.copbio.2024.103138. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCRs) are important pharmaceutical targets, working as entry points for signaling pathways involved in metabolic, neurological, and cardiovascular diseases. Although small molecules remain the major GPCR drug type, biologic therapeutics, such as peptides and antibodies, are increasingly found among clinical trials and Food and Drug Administration (FDA)-approved drugs. Here, we review state-of-the-art technologies for the engineering of biologics that target GPCRs, as well as proof-of-pr...
Source: Current Opinion in Biotechnology - May 10, 2024 Category: Biotechnology Authors: McKenna L Downey Pamela Peralta-Yahya Source Type: research

Tacrolimus Related Acute Pancreatitis: An Observational, Retrospective, Pharmacovigilance Study
This study uses the Food and Drug Administration Adverse Event Reporting System (FAERS) to investigate the risk signal of acute pancreatitis associated with calcineurin inhibitors (CNIs), with a focus on tacrolimus.METHODS: We conducted an observational retrospective pharmacovigilance study utilizing the FAERS database, encompassing data from its inception to the third quarter of 2023. The assessment of the association between CNIs and acute pancreatitis was carried out using the Information Component (IC) and Reporting Odds Ratio (ROR). Logistic regression analysis was employed to elucidate factors contributing to fatal o...
Source: Clinical Therapeutics - May 10, 2024 Category: Drugs & Pharmacology Authors: Hui Yang Zhuoling An Yong Zhao Hezhe Lu Source Type: research

Antiobesity interventions: options, evidence and value
Adults with obesity have more choices than ever before of therapies that reduce body mass index (BMI) and consequently improve related chronic health conditions. Bariatric procedures are among the most well-studied options with the longest follow-up. Despite achieving the greatest reductions in BMI and rates of diabetes remission, uptake of bariatric surgery remains low. Endoscopic sleeve gastroplasty (ESG), a minimally invasive approach that avoids any skin incisions, reduced BMI and improved metabolic health conditions compared with lifestyle intervention (LI) in one randomised trial, and the first devices for ESG were a...
Source: Gut - May 10, 2024 Category: Gastroenterology Authors: Elkin, E. B., Hur, C. Tags: Gut Commentary Source Type: research