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Exploring the relationship between house dust mites and asthma
Expert Rev Clin Immunol. 2024 Apr 23:1-4. doi: 10.1080/1744666X.2024.2346585. Online ahead of print.NO ABSTRACTPMID:38652085 | DOI:10.1080/1744666X.2024.2346585 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Luis Caraballo Source Type: research

New Discoveries in the genetics and genomics of systemic juvenile idiopathic arthritis
Expert Rev Clin Immunol. 2024 Apr 20. doi: 10.1080/1744666X.2024.2345868. Online ahead of print.ABSTRACTINTRODUCTION: Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory condition with onset in childhood. It is sporadic, but elements of its stereotypical innate immune responses are likely genetically encoded by both common variants with small effect sizes and rare variants with larger effects.AREAS COVERED: Genomic investigations have defined the unique genetic architecture of sJIA. Identification of the class II HLA locus as the strongest sJIA risk factor for the first time brought attention to T lympho...
Source: Expert Review of Clinical Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Mariana Correia Marques Michael J Ombrello Grant S Schulert Source Type: research

The role of immune reconstitution in relapse after allogeneic hematopoietic stem cell transplantation
Expert Rev Clin Immunol. 2024 May;20(5):513-524. doi: 10.1080/1744666X.2023.2299728. Epub 2024 Jan 10.ABSTRACTINTRODUCTION: Leukemia relapse following stem cell transplantation remains a significant barrier to long-term remission. Timely and balanced immune recovery after transplantation is crucial for preventing leukemia relapse.AREAS COVERED: After an extensive literature search of PubMed and Web of Science through October 2023, we provide an overview of the dynamics of immune reconstitution and its role in controlling leukemia relapse. We also discuss strategies to promote immune reconstitution and reduce disease recurr...
Source: Expert Review of Clinical Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Xu-Ying Pei Xiao-Jun Huang Source Type: research

Basophil activation test in the food allergy clinic: its current use and future applications
Expert Rev Clin Immunol. 2024 Apr 10:1-8. doi: 10.1080/1744666X.2024.2336568. Online ahead of print.ABSTRACTINTRODUCTION: The basophil activation test (BAT) has shown evidence of high sensitivity and high specificity to support the diagnosis of IgE-mediated allergy. It is a functional test that uses live cells analyzed by flow cytometry and thus needs to be performed within 24h of blood collection. BAT has shown to be reproducible and reliable when tested in a clinical diagnostic laboratory with standardized protocols and flow cytometry settings.AREAS COVERED: In this review, we summarize the evidence to support clinical u...
Source: Expert Review of Clinical Immunology - April 9, 2024 Category: Allergy & Immunology Authors: Marcel M Bergmann Alexandra F Santos Source Type: research

Basophil activation test in the food allergy clinic: its use current use and future applications
Expert Rev Clin Immunol. 2024 Apr 9. doi: 10.1080/1744666X.2024.2336568. Online ahead of print.ABSTRACTThe basophil activation test (BAT) has shown evidence of high sensitivity and high specificity to support the diagnosis of IgE-mediated allergy. It is a functional test that uses live cells analyzed by flow cytometry and thus needs to be performed within 24 h of blood collection. BAT has shown to be reproducible and reliable when tested in a clinical diagnostic laboratory with standardized protocols and flow cytometry settings. BAT has recently been included in Clinical Guidelines of Food Allergy Diagnosis and its impleme...
Source: Expert Review of Clinical Immunology - April 9, 2024 Category: Allergy & Immunology Authors: Marcel M Bergmann Alexandra F Santos Source Type: research

Neuro-ophthalmic challenges and multi-morbidity in vasculitis among the older adults
Expert Rev Clin Immunol. 2024 Apr 9:1-11. doi: 10.1080/1744666X.2024.2339893. Online ahead of print.ABSTRACTINTRODUCTION: Vasculitides are a heterogeneous group of disorders producing inflammation of blood vessels (e.g. arteries or veins). All major vasculitides potentially have ophthalmological symptoms and signs including visual loss. Co-morbidity, multimorbidity, polypharmacy, and geriatric syndromes all play important roles in patient outcomes for these rheumatic conditions in the elderly. This monograph reviews the NCBI PubMed database (Feb 2023) literature on the neuro-ophthalmic and geriatric considerations in vascu...
Source: Expert Review of Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Caezaan Keshvani Noor Laylani Pamela Davila-Siliezar Jonathan Kopel Andrew G Lee Source Type: research

Neuro-ophthalmic challenges and multi-morbidity in vasculitis among the older adults
Expert Rev Clin Immunol. 2024 Apr 4. doi: 10.1080/1744666X.2024.2339893. Online ahead of print.ABSTRACTINTRODUCTION: Vasculitides are a heterogeneous group of disorders producing inflammation of blood vessels (e.g. arteries or veins). All major vasculitides potentially have ophthalmological symptoms and signs including visual loss. Co-morbidity, multimorbidity, polypharmacy and geriatric syndromes all play important roles in patient outcomes for these rheumatic conditions in the elderly. This monograph reviews the NCBI PubMed database (Feb 2023) literature on the neuro-ophthalmic and geriatric considerations in vasculitis....
Source: Expert Review of Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Caezaan Keshvani Noor Laylani Pamela Davila-Siliezar Jonathan Kopel Andrew G Lee Source Type: research