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Current progress of CAR-T-cell therapy for patients with multiple myeloma
Int J Hematol. 2024 May 23. doi: 10.1007/s12185-024-03794-0. Online ahead of print.ABSTRACTCurrently available chimeric antigen receptor (CAR)-engineered T-cell therapies targeting B-cell maturation antigen (BCMA), namely, idecabtagene vicleucel and ciltacabtagene autoleucel, have shown marked efficacy against relapsed and refractory multiple myeloma. However, further improvement in CAR-T-cell function is warranted as most patients treated with these products eventually relapse due to various mechanisms such as antigen loss and T-cell dysfunction or disappearance. Strategies for improving CAR-T-cell function include target...
Source: International Journal of Hematology - May 22, 2024 Category: Hematology Authors: Takahiro Nakashima Yuki Kagoya Source Type: research

A review of the Augustine blood group system
Int J Hematol. 2024 May 20. doi: 10.1007/s12185-024-03791-3. Online ahead of print.ABSTRACTAugustine is a newly identified blood group system comprising four antigens, one of which is the high-frequency antigen Ata in the original "series". Four antigens are located on a multipass membrane glycoprotein equilibrative nucleoside transporter 1 (ENT1), and equilibrative nucleoside transporter is encoded by SLC29A1. In 2016, the International Society of Blood Transfusion (ISBT) recognised Augustine as a blood group system and numbered it as 036. The glycoprotein ENT1 transports nucleotides into cells to participate in the synth...
Source: International Journal of Hematology - May 20, 2024 Category: Hematology Authors: Jing Zhong Chunping Mo Yan Zhang Lingbo Li Source Type: research

Retrospectively diagnosed autoimmune VWF deficiency in a patient with repeated hemorrhagic events after two common colds
Int J Hematol. 2024 May 18. doi: 10.1007/s12185-024-03782-4. Online ahead of print.ABSTRACTAutoimmune von Willebrand factor (VWF) deficiency (AiVWFD) caused by anti-VWF autoantibodies is a rare bleeding disorder, whereas "non-immune" acquired von Willebrand syndrome (AVWS) caused by other etiologies is more common. Therefore, only 40 patients with AiVWFD have been identified in Japan through an ongoing nationwide survey on autoimmune coagulation factor deficiencies. This may be due to the inability to efficiently detect anti-VWF antibodies, as anti-VWF antibody testing is not routine. An 80-year-old Japanese woman develope...
Source: International Journal of Hematology - May 18, 2024 Category: Hematology Authors: Yoshiyuki Ogawa Akitada Ichinose Kunio Yanagisawa Masayoshi Souri Tsukasa Osaki Shuhei Kanaya Hiroshi Handa Source Type: research

Reply to the Dr. Murphy's comment
Int J Hematol. 2024 May 16. doi: 10.1007/s12185-024-03788-y. Online ahead of print.NO ABSTRACTPMID:38755493 | DOI:10.1007/s12185-024-03788-y (Source: International Journal of Hematology)
Source: International Journal of Hematology - May 16, 2024 Category: Hematology Authors: Hirokazu Kashiwagi Source Type: research

Outcome of 3q26.2/MECOM rearrangements in chronic myeloid leukemia
CONCLUSION: Outcomes of 3q26.2/MECOM-rearranged CML are poor despite the availability of multiple BCR::ABL1 tyrosine kinase inhibitors (TKIs). Third-generation TKIs in combination with novel agents and possible allo-SCT could be considered given the poor outcomes and resistance to second-generation TKIs.PMID:38748089 | DOI:10.1007/s12185-024-03787-z (Source: International Journal of Hematology)
Source: International Journal of Hematology - May 15, 2024 Category: Hematology Authors: Hiroki Akiyama Hagop Kantarjian Elias Jabbour Ghayas Issa Fadi G Haddad Nicholas J Short Shimin Hu Jo Ishizawa Michael Andreeff Koji Sasaki Source Type: research

Metabolic dependencies of acute myeloid leukemia stem cells
Int J Hematol. 2024 May 15. doi: 10.1007/s12185-024-03789-x. Online ahead of print.ABSTRACTAcute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML cells termed leukemia stem cells (LSCs) that are implicated in AML development, chemoresistance, and relapse. An emerging area of research in AML focuses on identifying and targeting the aberrant metabolism in LSCs. Dysregulated metabolism is involved in sustaining functional properties of LSCs, impeding myeloid differentiation, and evading programmed cell death, both in the process of leukemogenesis and in respons...
Source: International Journal of Hematology - May 15, 2024 Category: Hematology Authors: Xiangguo Shi Mengdie Feng Daisuke Nakada Source Type: research

Serum monoclonal immunoglobulin light-chain detection differs between immunofixation electrophoresis methods in patients with AL amyloidosis
In this study, we examined the detection rate of serum M protein in newly diagnosed AL amyloidosis patients and analyzed differences in M protein detection between IFE methods. Among 60 patients newly diagnosed with AL amyloidosis, 22 had undetectable serum M protein by IFE with the Epalyzer2 system. Samples with undetectable M protein had significantly lower involved serum-free light-chain (iFLC) and a smaller difference between involved and uninvolved serum-free light-chain (dFLC) values than samples with IFE-detectable monoclonal light chains. When samples that tested negative for M protein by the Epalyzer2 system were ...
Source: International Journal of Hematology - May 13, 2024 Category: Hematology Authors: Yawara Kawano Nao Nishimura Jun-Ichirou Yasunaga Source Type: research