International Journal of Hematology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Risk factors and remaining challenges in the treatment of acute promyelocytic leukemia
This article provides a comprehensive review of APL risk factors, taking into account the treatment approach, and explores the challenges associated with APL treatments.PMID:38386203 | DOI:10.1007/s12185-023-03696-7 (Source: International Journal of Hematology)
Source: International Journal of Hematology - February 22, 2024 Category: Hematology Authors: Yasuhisa Yokoyama Source Type: research

Measurement of serum hepcidin-25 by latex agglutination in healthy volunteers and patients with hematologic disorders
In this study, we employed a recently developed latex agglutination method integrated with a readily available automated analyzer to quantify serum hepcidin-25 levels in both volunteers recruited from personnel of our hospital (n = 93) and patients with various hematological disorders (n = 112). Our findings unveiled a robust positive correlation between serum hepcidin-25 and ferritin, as well as C-reactive protein levels, in both volunteers and patients. Among the patients with hematological disorders, there was a noteworthy negative correlation between hepcidin-25 levels and hemoglobin concentrations, as well as reticulo...
Source: International Journal of Hematology - February 19, 2024 Category: Hematology Authors: Hiroshi Kawabata Naoki Miyazawa Yumi Matsuda Misaki Satobe Yasushi Mizogami Yoko Kuriyama Tomomi Sakai Minako Mori Michio Sasa Source Type: research

Correlation of ex vivo and in vivo ammonia production with L-asparaginase biological activity in adults with lymphoid malignancies
Int J Hematol. 2024 Feb 16. doi: 10.1007/s12185-024-03718-y. Online ahead of print.ABSTRACTSilent inactivation of L-asparaginase (L-Asp) represents rapid clearance of L-Asp by anti-L-Asp IgG antibodies without clinical symptoms. Measurement of L-Asp activity is the gold standard for diagnosis of silent inactivation, but this test is not commercially available in Japan as of 2023. We evaluated ex vivo and in vivo ammonia production in relation to L-Asp activity. Blood samples from ten adult patients treated with L-Asp were collected to measure ammonia levels and L-Asp activity before the first dose and 24 h after the last d...
Source: International Journal of Hematology - February 16, 2024 Category: Hematology Authors: Takayuki Nakamura Shuki Oya Hidetoshi Ozawa Yoshimi Maehiro Seiya Muta Masahiro Umeda Yusuke Takaki Toshinobu Fukuyama Yoshitaka Yamasaki Maki Yamaguchi Kazutoshi Aoyama Fumihiko Mouri Yoshiki Naito Koji Nagafuji Source Type: research

Chimeric antigen receptor T-cell therapy after COVID-19 in refractory high-grade B-cell lymphoma
We report the case of a 70-year-old woman who developed COVID-19 immediately before CAR-T therapy for high-grade B-cell lymphoma. She received Tixagevimab-Cilgavimab chemotherapy and radiation therapy but never achieved remission. She was transferred to our hospital for CAR-T therapy, but developed COVID-19. Her symptoms were mild and she was treated with long-term molnupiravir. On day 28 post-infection, lymphodepleting chemotherapy was restarted after a negative polymerase chain reaction (PCR) test was confirmed. The patient did not experience recurrence of COVID-19 symptoms or severe cytokine release syndrome. Based on t...
Source: International Journal of Hematology - February 13, 2024 Category: Hematology Authors: Kenta Hayashino Keisuke Seike Kanako Fujiwara Kaho Kondo Chisato Matsubara Toshiki Terao Wataru Kitamura Chihiro Kamoi Hideaki Fujiwara Noboru Asada Hisakazu Nishimori Daisuke Ennishi Keiko Fujii Nobuharu Fujii Ken-Ichi Matsuoka Yoshinobu Maeda Source Type: research

Dysregulated hemostasis in acute promyelocytic leukemia
Int J Hematol. 2024 Feb 11. doi: 10.1007/s12185-024-03708-0. Online ahead of print.ABSTRACTAcute promyelocytic leukemia (APL) is associated with a high incidence of early death, which occurs within 30 days of diagnosis. The major cause of early death in APL is severe bleeding, particularly intracranial bleeding. Although APL is known to be associated with activation of coagulation, hyperfibrinolysis, and thrombocytopenia, the precise mechanisms that cause bleeding have not yet been elucidated. I propose that a combination of four pathways may contribute to bleeding in APL: (1) tissue factor, (2) the urokinase plasminogen a...
Source: International Journal of Hematology - February 10, 2024 Category: Hematology Authors: Yohei Hisada Source Type: research

Age-related variation in coagulation factors in non-valvular atrial fibrillation patients receiving direct oral anticoagulants
Int J Hematol. 2024 Feb 9. doi: 10.1007/s12185-024-03712-4. Online ahead of print.ABSTRACTAge is a significant risk factor for ischemic stroke. However, the influence of aging on coagulation parameters in non-valvular atrial fibrillation (NVAF) patients treated with direct oral anticoagulants (DOACs) remains unclear. A total of 775 samples were collected from 224 NVAF patients receiving apixaban, edoxaban or rivaroxaban. The samples were categorized into three age groups: (i) ≤ 64 years, (ii) 65-74 years, and (iii) ≥ 75 years (apixaban: N = 48, 108, 119; edoxaban: N = 63, 68, 126; rivaroxaban: N = 115, 90, 38, respecti...
Source: International Journal of Hematology - February 9, 2024 Category: Hematology Authors: Osamu Kumano Shinya Suzuki Masako Yamazaki Yoshimori An Masahiro Yasaka Masahiro Ieko Japanese Study Group for the Assessment of Direct Oral Anticoagulants Source Type: research

Cancer-associated thrombosis and bleeding
Int J Hematol. 2024 Feb 4. doi: 10.1007/s12185-024-03716-0. Online ahead of print.ABSTRACTDevelopment of thrombosis is closely associated with poor prognosis in cancer patients. Cancer patients often fulfill Virchow's triad of hyper-coagulable state, vascular endothelial injury, and venous stasis. Cancer cells aberrantly express a variety of procoagulant factors, including tissue factor and podoplanin. Chemotherapeutic agents and radiation cause vascular endothelial injury, and reduced daily activity and bed rest for chemotherapy lead to venous stasis. Due to these factors, cancer patients are at high risk of developing th...
Source: International Journal of Hematology - February 4, 2024 Category: Hematology Authors: Takayuki Ikezoe Source Type: research

Aplastic anemia: history and recent developments in diagnosis and treatment
Int J Hematol. 2024 Feb 4. doi: 10.1007/s12185-024-03715-1. Online ahead of print.ABSTRACTAcquired aplastic anemia is an immune-mediated disease that targets hematopoietic stem cells, which is diagnosed by findings of peripheral blood pancytopenia and hypocellular bone marrow. Although the diagnostic definition is simple, differential diagnosis from other overlapping hematopoietic disorders such as hypoplastic myelodysplastic syndrome and inherited bone marrow failure syndrome is not easy. Immune suppressive therapy and allogeneic hematopoietic stem cell transplantation are important treatment approaches for aplastic anemi...
Source: International Journal of Hematology - February 3, 2024 Category: Hematology Authors: Yasushi Onishi Source Type: research

Nelarabine-containing salvage therapy and conditioning regimen in transplants for pediatric T-cell acute lymphoblastic leukemia and lymphoma
Int J Hematol. 2024 Feb 1. doi: 10.1007/s12185-023-03701-z. Online ahead of print.ABSTRACTTherapy for relapsed or refractory (r/r) T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) in children is challenging, and new treatment methods are needed. We retrospectively analyzed eight patients with r/r T-ALL (five patients) and T-LBL (three patients) who were treated with nelarabine (NEL) plus etoposide, cyclophosphamide, and intrathecal therapy, administered 3 days apart. Five patients achieved a complete response, and the other three achieved a partial response (PR). All patients underwent ...
Source: International Journal of Hematology - February 1, 2024 Category: Hematology Authors: Masato Yanagi Makiko Mori Mamoru Honda Yuichi Mitani Masafumi Seki Kohei Fukuoka Koichi Oshima Yuki Arakawa Katsuyoshi Koh Source Type: research