International Journal of Hematology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Longitudinal dynamic changes in factor VIII inhibitor titers in patients with hemophilia A and inhibitors receiving emicizumab prophylaxis
Int J Hematol. 2023 Oct 6. doi: 10.1007/s12185-023-03667-y. Online ahead of print.ABSTRACTEmicizumab prophylaxis dramatically reduces bleeding events in patients with hemophilia A (PwHA) with or without factor VIII (FVIII) inhibitors. However, long-term dynamic changes in FVIII inhibitor titers during emicizumab prophylaxis remain to be investigated. We conducted a retrospective follow-up study of FVIII inhibitor titers after initiation of emicizumab prophylaxis in 25 PwHA carrying current or historical FVIII inhibitors. Nineteen PwHA had FVIII inhibitors at initiation of emicizumab prophylaxis (age: median 22 [range 4-60]...
Source: International Journal of Hematology - October 6, 2023 Category: Hematology Authors: Naruto Shimonishi Kana Sasai Kenichi Ogiwara Shoko Furukawa Yuto Nakajima Kuniyoshi Mizumachi Koji Yada Masahiro Takeyama Midori Shima Narumi Mizuno Keiji Nogami Source Type: research

Hematopoiesis in the spleen after engraftment in unrelated cord blood transplantation evaluated by < sup > 18 < /sup > F-FLT PET imaging
Int J Hematol. 2023 Oct 2. doi: 10.1007/s12185-023-03658-z. Online ahead of print.ABSTRACTCord blood is an important donor source for allogeneic hematopoietic stem cell transplantation (allo-HSCT), with its unique composition and quality of hematopoietic cells. The proliferation site and potency of infused hematopoietic stem cells in humans may vary between stem cell sources. We investigated this possibility in a prospective, exploratory study to assess hematopoietic dynamics using the radiopharmaceutical 3'-deoxy-3'-18F-fluorothymidine (18F-FLT), a thymidine analog used in positron emission tomography imaging, before allo...
Source: International Journal of Hematology - October 2, 2023 Category: Hematology Authors: Hiroaki Araie Naoko Hosono Tetsuya Tsujikawa Yasushi Kiyono Hidehiko Okazawa Takahiro Yamauchi Source Type: research

New-onset aplastic anemia after SARS-CoV-2 vaccination
Int J Hematol. 2023 Sep 28. doi: 10.1007/s12185-023-03666-z. Online ahead of print.ABSTRACTAplastic anemia (AA) is a rare autoimmune disease. Drugs, viruses, and radiation are among the most common etiologic factors, and most cases have immune pathophysiology. SARS-CoV-2 vaccines have been linked with rare side effects, including cases of acquired aplastic anemia. Here we review all the reported cases of new-onset AA after SARS-CoV-2 vaccination, and discuss their clinical characteristics and management. 18 patients in these case reports had a median age of 58 years. The time from vaccination to onset of aplastic anemia ra...
Source: International Journal of Hematology - September 28, 2023 Category: Hematology Authors: Elena Chatzikalil Antonis Kattamis Panagiotis Diamantopoulos Elena E Solomou Source Type: research

Regulation of von Willebrand factor by ADAMTS13 ameliorates lipopolysaccharide-induced lung injury in mice
This study suggested that ADAMTS13 protein and other VWF-targeting agents may be a novel therapeutic option for treatment of pulmonary inflammatory diseases.PMID:37759076 | DOI:10.1007/s12185-023-03668-x (Source: International Journal of Hematology)
Source: International Journal of Hematology - September 27, 2023 Category: Hematology Authors: Yu Onodera Seiji Mitani Chihiro Hosoda Yoko Takabayashi Asuka Sakata Ryohei Kawasaki Ryota Mori Chiaki Ohshima Kenji Nishio Mitsuhiko Sugimoto Kenji Soejima Nigel Mackman Midori Shima Kohei Tatsumi Source Type: research