International Journal of Hematology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Histiocytic sarcoma following CAR T-cell therapy: a case report
CONCLUSION: Our case illustrates a rare complication after CART therapy. The diagnosis and treatment of histiocytic sarcoma pose many challenges.PMID:38294639 | DOI:10.1007/s12185-023-03695-8 (Source: International Journal of Hematology)
Source: International Journal of Hematology - January 31, 2024 Category: Hematology Authors: Kang An Yan He Yanjing Tang Xiaoyan Gu Juan Qian Benshang Li Source Type: research

Diffuse large B-cell lymphoma of the skull vault
Int J Hematol. 2024 Jan 30. doi: 10.1007/s12185-024-03717-z. Online ahead of print.NO ABSTRACTPMID:38289575 | DOI:10.1007/s12185-024-03717-z (Source: International Journal of Hematology)
Source: International Journal of Hematology - January 30, 2024 Category: Hematology Authors: Satoshi Ichikawa Hisayuki Yokoyama Noriko Fukuhara Ryo Ichinohasama Hideo Harigae Source Type: research

STAT6 mutations enriched at diffuse large B-cell lymphoma relapse reshape the tumor microenvironment
We reported that STAT6D419 mutations are enriched in relapsed/refractory DLBCL (rrDLBCL) samples, suggesting that JAK/STAT signaling plays a role in therapeutic resistance. We hypothesized that STAT6D419 mutations can improve DLBCL cell survival by reprogramming the microenvironment to sustain STAT6 activation. Thus, we investigated the role of STAT6D419 mutations on DLBCL cell growth and its microenvironment. We found that phospho-STAT6D419N was retained in the nucleus longer than phospho-STAT6WT following IL-4 stimulation, and STAT6D419N recognized a more restricted DNA-consensus sequence than STAT6WT. Upon IL-4 inductio...
Source: International Journal of Hematology - January 29, 2024 Category: Hematology Authors: Alexandre Benoit Madelyn J Abraham Sheena Li John Kim Roger Estrada-Tejedor Rowa Bakadlag Nivetha Subramaniam Kiran Makhani Cynthia Guilbert Raymond Tu Matthew Salaciak Kathleen Oros Klein Krysta Mila Coyle Laura K Hilton Raoul Santiago Svetlana Dmitrienk Source Type: research

A systematic review and meta-analysis of recombinant human soluble thrombomodulin for the treatment of DIC associated with hematological malignancies
CONCLUSION: Use of rhTM in patients with hematological malignancy-associated DIC is strongly expected to be effective and safe.PMID:38270783 | DOI:10.1007/s12185-023-03704-w (Source: International Journal of Hematology)
Source: International Journal of Hematology - January 25, 2024 Category: Hematology Authors: Noriaki Kawano Masahiko Fukatsu Kazuma Yamakawa Yoshinobu Seki Hideo Wada Kohji Okamoto Takayuki Ikezoe Source Type: research

Cancer-associated thrombosis in hematologic malignancies
This article summarizes the current understanding, risk factors, prediction models, and optimal prevention and treatment strategies of CAT in hematologic malignancies on a disease-by-disease basis, including acute leukemia, lymphoma, myeloma, and myeloproliferative neoplasms. Specific considerations of novel molecular targeted therapeutics introduced in recent years, such as immunomodulatory drugs and tyrosine kinase inhibitors, are also discussed based on the latest clinical trials.PMID:38270784 | DOI:10.1007/s12185-023-03690-z (Source: International Journal of Hematology)
Source: International Journal of Hematology - January 25, 2024 Category: Hematology Authors: Masahiko Fukatsu Takayuki Ikezoe Source Type: research

TBI, etoposide, and cyclophosphamide conditioning for intermediate-risk relapsed childhood acute lymphoblastic leukemia
CONCLUSION: Allo-HSCT based on post-induction MRD with TBI + ETP + CY conditioning was feasible in Japanese children with intermediate-risk relapsed ALL.PMID:38267673 | DOI:10.1007/s12185-024-03710-6 (Source: International Journal of Hematology)
Source: International Journal of Hematology - January 24, 2024 Category: Hematology Authors: Hideaki Ueki Chitose Ogawa Hiroaki Goto Masanori Nishi Junko Yamanaka Shinji Mochizuki Takuro Nishikawa Tadashi Kumamoto Ritsuo Nishiuchi Atsushi Kikuta Shohei Yamamoto Shunji Igarashi Atsushi Sato Toshinori Hori Akiko M Saito Tomoyuki Watanabe Takao Degu Source Type: research

Pretransplant hepatomegaly is linked to relapse in patients with leukemia and myelodysplastic syndrome not in remission
In conclusion, our findings suggest that the LI may be a risk factor for relapse in NonCR patients after allo-HCT.PMID:38252235 | DOI:10.1007/s12185-023-03707-7 (Source: International Journal of Hematology)
Source: International Journal of Hematology - January 22, 2024 Category: Hematology Authors: Yusuke Okayama Naonori Harada Yosuke Makuuchi Masatomo Kuno Teruhito Takakuwa Hiroshi Okamura Asao Hirose Mika Nakamae Mitsutaka Nishimoto Yasuhiro Nakashima Hideo Koh Masayuki Hino Hirohisa Nakamae Source Type: research

Acute suppression of translation by hyperthermia enhances anti-myeloma activity of carfilzomib
Int J Hematol. 2024 Jan 22. doi: 10.1007/s12185-023-03706-8. Online ahead of print.ABSTRACTHyperthermia is a unique treatment option for cancers. Multiple myeloma (MM) remains incurable and innovative therapeutic options are needed. We investigated the efficacy of hyperthermia and carfilzomib in combination against MM cells. Although MM cell lines exhibited different susceptibilities to pulsatile carfilzomib treatment, mild hyperthermia at 43℃ induced MM cell death in all cell lines in a time-dependent manner. Hyperthermia and carfilzomib cooperatively induced MM cell death even under suboptimal conditions. The pro-survi...
Source: International Journal of Hematology - January 22, 2024 Category: Hematology Authors: Tomoko Maruhashi Hirokazu Miki Kimiko Sogabe Asuka Oda Ryohei Sumitani Masahiro Oura Mamiko Takahashi Takeshi Harada Shiro Fujii Shingen Nakamura Kiyoe Kurahashi Itsuro Endo Masahiro Abe Source Type: research

Multiple myeloma presenting as nodular hepatic lesions mimicking hepatocellular carcinoma
Int J Hematol. 2024 Jan 22. doi: 10.1007/s12185-024-03719-x. Online ahead of print.NO ABSTRACTPMID:38253959 | DOI:10.1007/s12185-024-03719-x (Source: International Journal of Hematology)
Source: International Journal of Hematology - January 22, 2024 Category: Hematology Authors: Naonori Harada Source Type: research

Differences between Japanese new criteria and pregnancy-specific modified ISTH DIC scores for obstetrical DIC diagnosis
Int J Hematol. 2024 Jan 23. doi: 10.1007/s12185-023-03702-y. Online ahead of print.ABSTRACTThe new Japanese diagnostic criteria for obstetrical disseminated intravascular coagulation (DIC) (tentative version) were released in June 2022. We aimed to demonstrate the differences in characteristics between women with DIC diagnosed using the new Japanese criteria and those diagnosed using the pregnancy-specific modified International Society on Thrombosis and Hemostasis DIC score, also known as the pregnancy-specific modified ISTH DIC score, which was released in 2014. In this retrospective cohort study, all participants were r...
Source: International Journal of Hematology - January 22, 2024 Category: Hematology Authors: Mamoru Morikawa Akio Kamiya Aya Yoshida Shuhei Nishibata Hidetaka Okada Source Type: research

Acute accumulation of PIM2 and NRF2 and recovery of β5 subunit activity mitigate multiple myeloma cell susceptibility to proteasome inhibitors
Int J Hematol. 2024 Jan 21. doi: 10.1007/s12185-023-03705-9. Online ahead of print.ABSTRACTResistance to proteasome inhibitors (PIs) has emerged as an important clinical issue. We investigated the mechanisms underlying multiple myeloma (MM) cell resistance to PIs. To mimic their pharmacokinetic/pharmacodynamic (PK/PD) profiles, MM cells were treated with bortezomib and carfilzomib for 1 h at concentrations up to 400 and 1,000 nM, respectively. Susceptibility to these PIs markedly varied among MM cell lines. Pulsatile treatments with PIs suppressed translation, as demonstrated by incorporation of puromycin at 24 h in PI-sus...
Source: International Journal of Hematology - January 21, 2024 Category: Hematology Authors: Kimiko Sogabe Shingen Nakamura Yoshiki Higa Hirokazu Miki Asuka Oda Tomoko Maruhashi Ryohei Sumitani Masahiro Oura Mamiko Takahashi Masafumi Nakamura Yusaku Maeda Tomoyo Hara Hiroki Yamagami Shiro Fujii Kumiko Kagawa Shuji Ozaki Kiyoe Kurahashi Itsuro End Source Type: research

Knockdown of the Shwachman-Diamond syndrome gene, SBDS, induces galectin-1 expression and impairs cell growth
Int J Hematol. 2024 Jan 19. doi: 10.1007/s12185-024-03709-z. Online ahead of print.ABSTRACTShwachman-Diamond syndrome (SDS) is an autosomal recessive disorder characterized by exocrine pancreatic insufficiency and bone marrow failure. The depletion of SBDS protein by RNA interference has been shown to cause inhibition of cell proliferation in several cell lines. However, the precise mechanism by which the loss of SBDS leads to inhibition of cell growth remains unknown. To evaluate the impaired growth of SBDS-knockdown cells, we analyzed Epstein-Barr virus-transformed lymphoblast cells (LCLs) derived from two patients with ...
Source: International Journal of Hematology - January 19, 2024 Category: Hematology Authors: Masafumi Yamaguchi Yukihiro Sera Hanae Toga-Yamaguchi Hirokazu Kanegane Yusuke Iguchi Kingo Fujimura Source Type: research

Burden of illness in Japanese patients with paroxysmal nocturnal hemoglobinuria receiving C5 inhibitors
This study contributes to understanding the unmet needs of the current therapies for PNH, highlighting the need for novel therapeutics.PMID:38243016 | DOI:10.1007/s12185-023-03698-5 (Source: International Journal of Hematology)
Source: International Journal of Hematology - January 19, 2024 Category: Hematology Authors: Naoshi Obara Kensuke Usuki Takeshi Hayashi Masato Fujii Takayuki Ikezoe Source Type: research

A case report of a truncated ABL1 mutation in 2 cases with Philadelphia chromosome-positive B cell precursor acute lymphoblastic leukemia
Int J Hematol. 2024 Feb;119(2):205-209. doi: 10.1007/s12185-023-03691-y. Epub 2024 Jan 18.ABSTRACTAcquired point mutations in the ABL1 gene are widely recognized as a cause of Philadelphia chromosome-positive B cell precursor acute lymphoblastic leukemia (Ph+ B-ALL) that is resistant to tyrosine kinase inhibitors, whereas there are few reports about other types of the ABL1 mutation. Here, we report 2 cases of Ph+ B-ALL gaining a partial deletion type mutation of the ABL1 gene (Δ184-274 mutation), which resulted in truncation of the ABL1 molecule and loss of kinase activity. In both cases, the disease was refractory to mul...
Source: International Journal of Hematology - January 18, 2024 Category: Hematology Authors: Kana Kato Shinsuke Takagi Hirofumi Takano Shinichi Tsunoda Otoya Watanabe Kyosuke Yamaguchi Kosei Kageyama Daisuke Kaji Yuki Taya Aya Nishida Kazuya Ishiwata Hisashi Yamamoto Go Yamamoto Yuki Asano-Mori Yukako Koike Shigeyoshi Makino Atsushi Wake Shuichi Source Type: research

HLA haploidentical stem cell transplantation from HLA homozygous donors to HLA heterozygous donors may have lower survival rates than haploidentical transplantation from HLA heterozygous donors to HLA heterozygous donors: a retrospective nationwide analysis
Int J Hematol. 2024 Feb;119(2):173-182. doi: 10.1007/s12185-023-03693-w. Epub 2024 Jan 17.ABSTRACTIn HLA haploidentical stem cell transplantation, patients and donors usually share one HLA haplotype and have one different HLA haplotype (hetero-to-hetero). However, there are rare cases of transplantation from HLA homozygous donors to heterozygous recipients (homo-to-hetero), resulting in mismatches only in the graft-versus-host direction. We previously reported that homo-to-hetero transplants have a lower survival rate in a mouse model than hetero-to-hetero transplants due to stronger graft-versus-host disease (GVHD) but in...
Source: International Journal of Hematology - January 17, 2024 Category: Hematology Authors: Keiko Fukunaga Kazuhiro Ikegame Hirohisa Nakamae Noriko Doki Takahiro Fukuda Yukio Kondo Takahide Ara Tetsuya Eto Yasuo Mori Ken-Ichi Matsuoka Yoshinobu Kanda Makoto Onizuka Yoshiko Atsuta Tatsuo Ichinohe Satoko Morishima Junya Kanda JSTCT HLA Working Gro Source Type: research